Profhilo
Profhilo
Profhilo represents a revolutionary breakthrough in aesthetic medicine – a treatment that doesn’t simply fill wrinkles or temporarily plump skin, but fundamentally transforms your skin quality from within. Hailed by The Times as THE treatment of the decade, Profhilo has become the gold standard for patients seeking natural, lasting rejuvenation without altering their facial features or expressions.
Unlike traditional dermal fillers that add volume to specific areas or anti-wrinkle injections that freeze muscles, Profhilo is the world’s first injectable bio-remodelling treatment. It works beneath the skin’s surface as a liquid moisturiser, spreading naturally through tissue layers to deliver intense hydration whilst simultaneously stimulating your body’s production of collagen, elastin, and adipocytes (fat cells). This unique dual-action approach addresses the root causes of skin ageing rather than merely masking its visible signs.
At the heart of Profhilo’s remarkable efficacy is its extraordinary concentration of ultra-pure hyaluronic acid (HA), 64mg in just 2ml, one of the highest concentrations available on the market today. What makes this formulation truly revolutionary is the patented NAHYCO® technology, which stabilises the hyaluronic acid without using harsh chemical cross-linking agents like BDDE that are found in traditional fillers. This thermal stabilisation process creates a unique hybrid cooperative complex combining both high molecular weight and low molecular weight hyaluronic acid molecules, delivering benefits that neither could achieve alone.
The high molecular weight HA provides immediate, profound hydration. Hyaluronic acid can hold up to 1,000 times its own weight in water, instantly plumping and refreshing tired, dehydrated skin within just 3-5 days of treatment. Meanwhile, the low molecular weight HA penetrates deeper into the dermal layers where it stimulates fibroblast activity, triggering sustained production of four different types of collagen and elastin over the following weeks and months. This progressive bio-stimulation creates genuine, lasting improvements in skin architecture and quality.
Clinical studies demonstrate remarkable results. Research shows Profhilo stimulates significant increases in collagen and elastin production, with improvements in dermal elasticity lasting up to six months after the initial treatment course. The treatment has been clinically proven using the Bio Aesthetic Points (BAP) technique to improve the malar-submalar area (cheeks and mid-face), with 64 patients showing instrumental and clinical improvements in skin quality.
Profhilo addresses multiple skin concerns simultaneously including skin laxity and loss of firmness, fine lines and crepey texture, dehydration and dullness, loss of elasticity and resilience, uneven skin tone and texture, and general signs of ageing across the face, neck, and body. The treatment is suitable for all skin types and ages—from younger patients in their late twenties seeking preventative care to mature patients requiring intensive rejuvenation.
What truly distinguishes Profhilo from other treatments is its versatility and natural-looking results. It can be used across multiple areas including the face (particularly effective for cheeks, jawline, and perioral regions), neck (addressing the notoriously difficult-to-treat neck laxity and horizontal neck lines), décolletage, hands (rejuvenating age-revealing thin, crepey skin), arms, knees, and abdomen where it effectively treats skin laxity. The treatment doesn’t change your facial contours, alter your expressions, or create an artificial “done” appearance, instead, it simply restores your skin to its healthiest, most youthful state.
The unique Bio Aesthetic Points (BAP) injection technique developed specifically for Profhilo is a game-changer in patient comfort and treatment efficiency. Rather than requiring numerous injections across the entire treatment area, Profhilo is strategically injected at just five precise anatomical points on each side of the face (a total of only ten injection sites). These carefully selected BAP points are located in anatomically safe areas with reduced risk of hitting major blood vessels, significantly minimising bruising whilst maximising the treatment’s spread and efficacy. Once injected, Profhilo’s unique formulation allows it to spread naturally through tissue layers over the following 4-6 weeks, dispersing like liquid honey to provide comprehensive coverage and even rejuvenation.
The treatment protocol is refreshingly simple and convenient. Profhilo requires just two initial treatment sessions spaced four weeks apart to achieve optimal results. This two-session approach allows the first treatment to deliver immediate hydration and initiate the bio-stimulation process, whilst the second treatment reinforces these effects and maximises collagen and elastin production. The full transformative effects become visible approximately 4-8 weeks after your second session, with improvements continuing to develop as your skin’s remodelling processes mature.
Results from Profhilo are progressive rather than instant, creating natural-looking improvements that develop beautifully over time. Friends and colleagues will notice you look refreshed, rested, and radiant, but they won’t be able to identify exactly what you’ve “had done”. This subtlety is precisely what makes Profhilo so appealing to discerning patients who value authenticity and natural beauty.
Book your consultation with Dr Parekh today and discover how Profhilo can fundamentally transform your skin quality, restore your natural radiance, and give you the confidence that comes with genuinely healthy, beautiful skin.
What to Expect
Treatment Duration:
Profhilo treatments typically take 10-30 minutes per session. The quick procedure makes it the perfect “lunchtime treatment” for busy professionals.
Longevity of Results:
Most patients experience 6-9 months of improved skin hydration, firmness, and radiance. Optimal results develop 4-8 weeks after the second treatment session.
Discomfort Score:
1-2/5 – The BAP technique uses only ten strategic injection points with ultra-fine needles, creating minimal discomfort. Most patients find the treatment very tolerable without anaesthetic, though numbing cream is available if desired.
Recovery Time:
Minimal downtime. Small bumps resembling mosquito bites at injection sites typically resolve within 2-24 hours. Mild tenderness or swelling subsides within a few days. Most patients return to normal activities immediately.
What Our Patients Say
Treatment Costs
Consultation
A comprehensive assessment of your skin condition, medical history, and aesthetic goals to determine your suitability for Profhilo and create a personalised bio-remodelling treatment plan. Refundable deposit of £150 needed.
FREE
Single Face Treatment Session
One complete Profhilo treatment session for the face using 2ml (64mg) of ultra-pure stabilised hyaluronic acid. Administered using the proven BAP technique with ten strategic injection points for optimal spread and results. Ideal for maintenance between treatment courses.
£450
Initial Treatment Course (2 Sessions)
The recommended initial protocol of two Profhilo treatment sessions for the face, spaced four weeks apart. This complete course provides optimal bio-remodelling, collagen stimulation, and lasting skin quality improvement. Course package offers excellent value.
£800
Face & Neck Treatment Course
Comprehensive Profhilo treatment addressing both face and neck concerns with two sessions spaced four weeks apart. Uses 3-4ml per session depending on treatment area and degree of laxity. Perfect for harmonious, complete rejuvenation of visible areas.
£1200-1600
Frequently Asked Questions
What happens during a treatment session?
Your Profhilo journey begins with a comprehensive consultation where Dr Parekh will assess your skin quality, discuss your specific concerns and aesthetic objectives, and review your complete medical history to ensure this treatment is appropriate for you.
Before your first treatment session, you’ll be asked to arrive with clean skin, completely free from makeup, moisturiser, lipstick, and sunscreen. Upon arrival for treatment, your skin will be thoroughly cleansed with antiseptic solution to minimise infection risk and ensure the treatment area is properly prepared. While topical anaesthetic cream is available if desired, most patients find Profhilo comfortable enough without numbing due to the limited number of injection points and ultra-fine needles used. If you do opt for numbing cream, it will be applied for approximately 20-30 minutes before proceeding.
The treatment itself involves injecting Profhilo at five precise Bio Aesthetic Points (BAP) on each side of your face, a total of only ten strategic injection sites carefully selected to maximise product spread whilst minimising discomfort and bruising risk. These specific anatomical points include the upper cheek (zygomatic protrusion, minimum 2cm from the outer corner of the eye), nasal base (at the intersection of a vertical line from the pupil and horizontal line from the nostril), tragus (at least 1cm in front of the ear tragus), jaw angle (1cm above the mandibular angle), and chin (1.5cm from the centre in the upper third). Using an ultra-fine 29-gauge needle, Dr Parekh will deliver 0.2ml of Profhilo per injection point into the subcutaneous layer just beneath your skin’s surface. The entire injection process typically takes just 10-30 minutes, making Profhilo a true “lunchtime procedure”. During injections, you may feel slight pressure, mild pinching, or brief stinging sensations, but these are generally minimal and well-tolerated.
Immediately following treatment, you’ll notice small raised bumps at each injection site. Tese resemble mosquito bites and are completely normal, representing the deposited Profhilo product before it begins spreading through your tissue. Dr Parekh will not massage these bumps, as Profhilo is designed to spread naturally through tissue layers over the following hours and days. You’ll be asked to remain at the clinic for approximately 10 minutes whilst applying an ice pack to the treated area to minimise swelling and bruising risk. The small bumps typically resolve within 2-24 hours as the product disperses beneath your skin like liquid honey.
You’ll receive comprehensive aftercare instructions including avoiding touching the treated area for at least 4-12 hours, waiting 12-24 hours before applying makeup, avoiding alcohol for 24 hours to reduce bruising risk, and avoiding strenuous exercise, excessive heat (saunas, steam rooms), and direct sun exposure for 24-48 hours post-treatment.
Over the subsequent 4-6 weeks, the Profhilo will continue spreading through your dermal layers, delivering deep hydration whilst simultaneously stimulating collagen and elastin production. You’ll return for your second treatment session exactly four weeks after the first, following the identical protocol to reinforce and maximise the bio-remodelling effects.
What is Profhilo and how does it work?
Profhilo is the world’s first injectable bio-remodelling treatment – a revolutionary product that fundamentally differs from traditional dermal fillers, anti-wrinkle injections, and even other skin boosters. It contains one of the highest concentrations of ultra-pure, stabilised hyaluronic acid (HA) available on the market, 64mg in just 2ml, formulated using the patented NAHYCO® thermal stabilisation technology. This innovative technology creates unique hybrid cooperative complexes combining both high molecular weight and low molecular weight hyaluronic acid without using harsh chemical cross-linking agents like BDDE found in traditional fillers.
When injected into your skin using the Bio Aesthetic Points (BAP) technique, Profhilo delivers a powerful dual-action mechanism that sets it apart from all other treatments. The first action is immediate, profound hydration. Hyaluronic acid is hydrophilic (water-loving) and can attract and hold up to 1,000 times its own weight in water. This creates an instant moisturising effect within 3-5 days of treatment, plumping your skin, improving dewiness, and restoring radiance to tired, dull complexions. The second action is progressive bio-stimulation. Over the following weeks and months, Profhilo stimulates your skin’s fibroblast cells to increase production of four different types of collagen, elastin, and even adipocytes (fat cells), fundamentally improving your skin’s structural integrity and regenerative capacity.
Unlike fillers that mechanically create volume through physical occupation of space, Profhilo initiates genuine biological remodelling of your skin tissue. It doesn’t add artificial volume, alter your facial contours, or change your natural expressions. Instead, it restores your skin’s own support structures, creating volume exactly where it’s naturally needed due to its exceptional spreadability. The stabilised formulation ensures prolonged stimulating activity on dermal cells, with effects lasting significantly longer than non-stabilised hyaluronic acid products. This bio-remodelling process creates lasting improvements in skin laxity, firmness, elasticity, hydration, texture, and overall quality, transforming your skin from within for results that look completely natural and genuinely healthy.
How long does the treatment take?
The Profhilo injection procedure itself is remarkably quick, typically taking just 10-30 minutes depending on the treatment area and whether you’re having your face alone or combining face and neck treatment. This brevity is possible thanks to the innovative BAP (Bio Aesthetic Points) technique, which requires only ten strategic injection points rather than numerous injections across the entire treatment area.
Your complete appointment time will be slightly longer, approximately 60-90 minutes, to allow for thorough skin cleansing, optional numbing cream application if desired (though most patients proceed without it), the treatment itself, and a brief post-treatment observation period with ice pack application. This efficiency makes Profhilo the perfect “lunchtime procedure” that can easily fit into your busy schedule without disrupting your day.
How soon will I see results?
Profhilo works progressively rather than delivering instant, dramatic transformation. This gradual development is what creates such natural-looking, authentic results. Many patients notice immediate improvements in skin hydration and a subtle plumping effect within the first few days following their initial treatment session as the hyaluronic acid begins attracting water into the skin.
During the first 1-3 days post-treatment, you’ll experience resolution of any injection site reactions and initial hydration effects as the immediate moisture-binding properties of hyaluronic acid take effect.
Throughout weeks 1-4 between your first and second treatments, you’ll notice progressive improvements in skin texture, increasing firmness, enhanced hydration, and early collagen stimulation effects developing. Many patients report receiving compliments during this phase, with friends commenting they look “refreshed,” “well-rested,” or “radiant,” though the changes remain beautifully subtle and natural.
The most dramatic and visible before-and-after differences become apparent approximately 4-8 weeks after your second treatment session, which is when the full bio-remodelling effects mature. At this stage, you’ll see significant improvement in skin firmness and elasticity, visible lifting effect particularly around the jawline and cheeks, reduction in fine lines and crepey texture, enhanced skin quality and luminosity, and natural-looking rejuvenation without volume changes or an artificial appearance. The improvements continue developing progressively for up to 12 weeks following your final treatment as collagen and elastin production peaks and your skin’s remodelling processes complete. This timeline of gradual enhancement ensures you never look like you’ve suddenly “had something done”, instead, you simply appear healthier, more vibrant, and well-rested, with skin that genuinely looks and feels younger.
Is the treatment painful?
One of Profhilo’s greatest advantages is its remarkable tolerability compared to other injectable treatments.
The vast majority of patients report minimal discomfort and find the treatment very manageable without anaesthetic. Several factors contribute to Profhilo’s comfortable treatment experience. First, the innovative BAP (Bio Aesthetic Points) technique requires only ten strategic injection points across the entire face rather than numerous injections, dramatically reducing overall discomfort. Second, the needles used are ultra-fine (typically 29-gauge), minimising the sensation during injection. Third, the injection depth is relatively shallow, just beneath the skin’s surface into the subcutaneous layer, which is less sensitive than deeper tissue injections.
Most patients describe the sensation as mild pinching, slight pressure, or brief stinging that lasts only a moment during each injection. The discomfort is generally rated as 1-2 out of 5, with many patients commenting that Profhilo is significantly more comfortable than they anticipated.
The entire injection process takes just 10-30 minutes, so any discomfort is very short-lived. While topical anaesthetic cream is available and can be applied for 20-30 minutes before treatment to numb the skin further, the majority of patients proceed without it and find the treatment perfectly tolerable. Some areas of the face may be slightly more sensitive than others, for example, the chin and areas closer to bone may feel more intense—but these sensations remain manageable.
After treatment, you may experience slight tenderness or mild discomfort around the injection sites for a day or two, but this is minimal and easily managed with cold compresses. It’s important to note that an experienced, skilled practitioner like Dr Parekh with a gentle injection technique significantly reduces discomfort during the procedure.
How long do the results last?
One of Profhilo’s most appealing features is the impressive longevity of results compared to many other aesthetic treatments. Following your initial two-session treatment course spaced four weeks apart, you can typically expect to enjoy the benefits for approximately 6-9 months.
Some patients experience effects lasting even longer, particularly after subsequent treatment courses as their skin condition continues improving with repeated stimulation. The extended duration of results occurs because Profhilo creates fundamental changes to your skin’s biological structure and regenerative capacity rather than simply providing temporary enhancement. The newly stimulated collagen and elastin continue providing structural support and improved skin quality long after the hyaluronic acid has naturally broken down and been absorbed by your body. The stabilised formulation using hybrid cooperative complexes makes Profhilo more resistant to enzymatic breakdown by hyaluronidase compared to non-stabilised hyaluronic acid products, contributing to its lasting effects.
Results typically reach their optimal peak around 8-12 weeks after your second treatment session, maintain this peak for several months, then gradually and naturally decline over the 6-9 month period. To sustain your rejuvenated skin quality and maintain continuous improvements, we recommend maintenance “top-up” treatments every 4-6 months following your initial course.
Many patients choose to follow a protocol of two complete treatment courses per year (in spring and autumn) to safeguard their bio-remodelled skin continuously.
The longevity of your individual results will depend on various factors including your age and baseline skin condition, degree of sun exposure and environmental damage, lifestyle factors such as smoking, alcohol consumption, and diet, overall health and metabolism, quality of your at-home skincare regimen and sun protection practices, and whether you maintain regular top-up sessions. With consistent maintenance treatments, many patients achieve cumulative improvements, with their skin quality continuing to enhance over time rather than simply maintaining the initial results.
Are there any side effects?
Profhilo is exceptionally safe when administered by qualified medical professionals, with minimal side effects.
The most common, expected reactions are mild and temporary, including small raised bumps at injection sites resembling mosquito bites (typically resolving within 2-24 hours as the product naturally spreads through tissue), mild redness or flushing in the treated area (generally subsiding within a few hours to 2-3 days), slight swelling or oedema, particularly in areas with thinner skin (decreasing within a few days and manageable with cold compresses), tenderness or sensitivity to touch around injection points (resolving within 2-3 days), and minor bruising at injection sites, though this is less common with the BAP technique due to strategically selected anatomically safe injection points (may persist for several days up to two weeks). These reactions are completely normal responses indicating your skin is accepting the treatment and beginning its bio-remodelling process.
More serious complications are extremely rare and typically only occur when treatments are performed by inexperienced or unqualified practitioners. Potential serious risks include severe skin reactions such as excessive swelling, ulcers, or rashes if the product is contaminated or poor injection technique is used; skin necrosis (tissue death) or even blindness if Profhilo is accidentally injected into a blood vessel, blocking blood supply; stroke risk if an artery is hit during injection; infections leading to permanent facial scarring if poor hygiene practices are followed; and allergic reactions manifesting as itching, hives, or difficulty breathing, though these are extremely rare given hyaluronic acid’s excellent biocompatibility.
It’s crucial to emphasise that when Profhilo is administered by appropriately qualified, trained, and experienced medical professionals like Dr Parekh who possess thorough understanding of facial anatomy and infection control standards, the risks of serious complications are vanishingly small. This is why it’s dangerous to purchase Profhilo online and attempt self-injection or allow anyone without proper medical qualifications to administer it. The risks far outweigh any perceived cost savings.
What should I do before the treatment?
To prepare for your Profhilo treatment and minimise potential complications, please follow these important pre-treatment guidelines.
On the day of your appointment, arrive with completely clean skin, free from all makeup, moisturiser, lipstick, mascara, and sunscreen. For at least one week before treatment, avoid consuming alcohol and discontinue taking blood-thinning medications and supplements such as aspirin, ibuprofen, other non-steroidal anti-inflammatory drugs (NSAIDs), vitamin E, fish oil, and Ginkgo Biloba, as these increase bruising risk (only discontinue prescribed medications after consulting your GP).
Do not schedule or receive a COVID vaccination for two weeks before your Profhilo treatment or for two weeks afterwards, as this can potentially increase inflammatory reactions. If you have a history of cold sores or herpes simplex virus, inform Dr Parekh during your consultation as prophylactic antiviral medication may be recommended to prevent an outbreak following treatment. If you are currently taking antibiotics for a skin infection in the treatment area or for an ear, sinus, nose, throat, or dental infection, you are unlikely to be suitable for Profhilo until the infection has fully cleared.
During your consultation, provide comprehensive information about all current medications and supplements you’re taking, any autoimmune conditions or immune system disorders, history of allergic reactions to any substances, previous aesthetic treatments and their outcomes, any existing medical conditions, and whether you are pregnant, breastfeeding, or planning pregnancy. If you have any concerns or questions before your treatment, don’t hesitate to contact the clinic. It’s always better to clarify details in advance rather than discovering contraindications on treatment day.
Can I return to normal activities after the treatment?
Yes, one of Profhilo’s most significant advantages is the minimal downtime, allowing you to resume most normal daily activities immediately following treatment. However, there are important temporary restrictions to optimise your healing, minimise side effects, and protect your investment in beautiful skin.
For the first 4-12 hours post-treatment, avoid touching, rubbing, or massaging the treated area to prevent displacing the product or introducing bacteria that could cause infection.
Wait at least 12-24 hours before applying makeup to allow the injection sites to close properly and reduce infection risk. Avoid consuming alcohol for at least 24 hours after your treatment, as alcohol can dilate blood vessels and significantly increase bruising risk. Avoid strenuous exercise, vigorous physical activity, and anything causing excessive sweating for 24-48 hours, as increased heart rate and blood flow can worsen swelling and bruising. Avoid exposure to excessive heat including saunas, steam rooms, hot baths, hot showers, and direct sun exposure for at least 24-48 hours post-treatment, as heat can exacerbate swelling and inflammation.
Apply cold compresses or ice packs intermittently to the treated area during the first 24 hours to minimise swelling and reduce bruising risk. Keep your skin well-hydrated with gentle, fragrance-free moisturisers and drink plenty of water to support the bio-remodelling process.
Once the initial healing period has passed (after 24-48 hours), always wear broad-spectrum SPF 50+ sunscreen daily to protect your newly rejuvenated skin from UV damage that accelerates ageing. The small bumps at injection sites typically resolve within 2-24 hours as the product naturally spreads through your tissue layers. Any mild redness, tenderness, or swelling usually subsides within a few days, allowing comfortable return to work, social activities, and your normal routine almost immediately.
Most patients schedule Profhilo treatments in the late afternoon or just before a rest day to allow the most visible initial effects to settle before returning to work and social engagements.
Who is an ideal candidate for this treatment?
Profhilo is remarkably versatile and suitable for a wide range of patients seeking genuine skin quality improvement rather than volumetric enhancement or feature alteration.
Ideal candidates include individuals with skin laxity and loss of firmness in the face, neck, or body, fine lines, wrinkles, and crepey texture, dehydrated, dull, or tired-looking skin lacking radiance, loss of skin elasticity and resilience, uneven skin tone and texture, early signs of ageing and those seeking preventative care, or those who want natural-looking rejuvenation without altering facial contours or expressions.
The treatment is safe and effective for all skin types, including darker skin tones, and is suitable for both men and women across a broad age range, from late twenties through to mature patients in their sixties, seventies, and beyond. Younger patients often choose Profhilo as preventative care, maintaining optimal skin quality before significant ageing signs develop, whilst mature patients use it for intensive rejuvenation, restoring firmness, hydration, and elasticity that have declined with age.
Profhilo is particularly valuable for patients who want to improve their overall skin quality without the risks, costs, and downtime associated with surgical procedures like facelifts; those who have tried other treatments with limited success or who want longer-lasting results than traditional hyaluronic acid skin boosters provide; individuals seeking natural-looking improvements that develop gradually rather than sudden, dramatic changes; those with difficult-to-treat areas like the neck, décolletage, or hands where other aesthetic treatments may not be suitable; and patients who want a treatment that complements and enhances other aesthetic procedures they’re already receiving.
During your consultation, Dr Parekh will thoroughly assess your skin condition, evaluate your areas of concern, review your complete medical history including current medications and allergies, discuss your aesthetic goals and expectations realistically, and determine whether Profhilo is the most appropriate treatment to help you achieve the healthy, rejuvenated, naturally beautiful skin you desire.
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